Research - Alcoholism
A randomized comparative trial in the management of Alcohol Dependence: Individualized Homoeopathy versus standard Allopathic Treatment
Raj K Manchanda1, KR Janardanan Nair2, Roja Varanasi1, Praveen Oberai1, R Bhuvaneswari2, Rupali Bhalerao1, M Gnnanaprakasham2, Maya Padmanabhan1, VA Siddiqui3
1 Central Council for Research in Homoeopathy, New Delhi, India
2 Central Research Institute (H), Kottayam, Kerala, India
3 Retired, Central Research Institute (H), Noida, Uttar Pradesh, India
Abstract
Objectives: This study was undertaken to compare the effects of IH with standard allopathic (SA) treatment.
Methods: A randomized controlled, open-label, comparative trial, was conducted, in which alcohol dependents were screened verbally using the CAGE scale. The participants 80 patients fulfilling the inclusion criteria were randomized either IH (n=40) or SA (n=40) and treated cum followed up for 12 months. The primary outcome was more than 50% reduction in the Severity of Alcohol Dependence Questionnaire [SADQ] rating scale at 12 th month. Data analysis was done for both intention-to-treat (ITT) and per-protocol (PP) populations.
Results: ITT analysis reflected 80% (n = 32) of the patients in IH and 37.5% (n = 15) of the patients in the SA responding to CI before 2.4 treatment with absolute difference was 42.5% (42.5 [95% confidence interval [CI]: 23.0, 61.6]) and estimated effect: 6.6 (95% C.I: 2.4, 18.2), P = 0.0002. A significant difference favoring IH was also observed in three out of four domains of WHO QOL-BREF. Statistically significant difference was found in the number of drinking days (median difference: −24.00; CI: −39.0-−8.0; P = 0.001) and number of drinks per drinking day (median difference: −6.3 [95% CI: −11.3-−1.9]; P = 0.004), favoring IH. The results showed a similar trend in PP analysis. Medicines found useful were Sulphur,Lycopodium clavatum, Arsenicum album, Nux vomica, Phosphorus, and Lachesis.
Conclusion: The results conclude that IH is not inferior to SA in the management of AD patients. More rigorous studies with large sample size are however desirable
Source : Indian Journal of Research in Homeopathy
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Managing acute alcohol withdrawal with Homoeopathy: A prospective, observational, multicentre exploratory study
Debadatta Nayak1, Saurav Arora2, Uttam Singh3, Nitali Borah4, JN Thakur4, Anil Khurana5, K. R. J. Nair6, Jaya Gupta7, Hari Singh8,Rajesh Kumar9, C Nayak10
1 Research Officer (H), Scientist - I, Central Council for Research in Homoeopathy, New Delhi, India
2 Former Senior Research Fellow (H), Central Council for Research in Homoeopathy, New Delhi, India
3 Former Senior Research Fellow (H), Society for Promotion of Youth and Masses, New Delhi, India
4 Former Senior Research Fellow (H), Society for Promotion of Youth and Masses, Darjeeling, West Bengal, India
5 Deputy Director (H), Scientist - IV, Central Council for Research in Homoeopathy, New Delhi, India
6 Assistant Director (H), Scientist - IV, Central Research Institute, Kottayam, Kerala, India
7 Research Officer, Scientist - IV, Central Council for Research in Homoeopathy, New Delhi, India
8 Former Research Officer, Central Council for Research in Homoeopathy, New Delhi, India
9 Director, Society for Promotion of Youth and Masses, New Delhi, India
10 Former Director General, Central Council for Research in Homoeopathy, New Delhi, India
Abstract
Background: Alcohol dependence is a common social problem which may be associated with other risk factors and co-morbidities. Abrupt cessation of alcohol intake may provoke an acute alcohol withdrawal phase with varying degrees of signs and symptoms. In conventional medical system, specific pharmacological interventions are used for management of Acute Alcohol Withdrawal (AAW). There exists a need to explore safe and holistic treatment of AAW. The present work reports the results of a prospective, observational, exploratory, multicentre trial (2008-2011) to assess the role of Homoeopathy in AAW.
Materials and Methods: Individualised Homoeopathy was given to 112 patients reporting with AAW. The clinical assessment was done for 05 days using Clinical Institute Withdrawal Assessment Scale of Alcohol-Revised (CIWA-Ar). Post-withdrawal phase, quality of life of patients was assessed at end of 01 st , 03 rd and 06 th month using World Health Organisation quality of life (WHOQOL)- BREF.
Results and Analysis: There was a significant decrease in CIWA-Ar mean scores and increase in quality of life score (P < 0.001). The most common remedies used were Arsenicum album, Lycopodium clavatum, Belladonna, Nux vomica and Pulsatilla.
Conclusion: The results of current observational pilot study suggest the promising use of Homoeopathy in the management of acute alcohol withdrawal. Further studies with large sample size and rigorous design are warranted.
Source : Indian Journal of Research in Homeopathy
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Intergroup transfer of anti-alcoholic effect of Nux vomica200 cH through the body of a live toad
Indrani Chakraborty 1,3, Nirmal C. Sukul2,3,4, Anirban Sukul 3,4,Rathin Chakravarty 3
1Department of Zoology, Vidyasagar College for Women, Kolkata, West Bengal, India
2Department of Zoology, Visva-Bharati, Santiniketan, West Bengal, India
3Molecular Homeopathy Research Unit, Kolkata, West Bengal, India
4Sukul Institute of Homeopathic Research, Santiniketan, West Bengal, India
ABSTRACT
Background: A homeopathic potency might often be given to nursing mothers for the treatment of their infants. Potencies above 12 cH exceed Avogadro’s number and thus ar etoo diluted so as to contain any original drug molecule. A potency is thought to be specifically structured water carrying the imprint of original drug molecules. It may induce changes in the water structure in the mother’s body and reach the suckling infant through her milk. Using a toad model,we recently demonstrated that the anti-alcoholic effect of Nux vomica200 cH could be transferred from one group of toads to another through capillary water carrying the information of Nux-v. Homeopathic potencies show UV spectra distinct from the hydro-ethanolic diluent medium. Does a potency remain effective even after passage through a living body?Objectives:To demonstrate that a potency effect might be transferred through the body of a live toad to other groups of toads connected to it through water. In addition, we sought to establish whether the UV spectra of the drug solution and the water connected tothe drug are similar in nature.Methods: A live toad was held vertically with one hind limb dipped in Nux-v200 cH solution in a beaker and another limb in distilled water in another beaker. The second beaker was connected by wet cotton threads encased in polythene tubes to 5 beakers, each one of which contained adult toads in distilled water. A batch of toads was directly treated with Nux-v200 cH. An equal number of toads in distilled water served as untreated control. After 30 min,the control and the two batches of treated toads were kept separately in 209 mM ethanol solution. Toads that stopped moving were placed in supine position on a dry surface. Failure to assume a normal sitting posture within a cutoff time of 60 sec was regarded as loss of righting reflex (RR). The experiment was replicated using a large number of toads. UV spectra of Nux-v200 cH solution and of water before and after connection with the drug were obtained.
Results: The percentage of toads that exhibitedRRlossin the 3groups increased with th etime of exposure to 209 mM ethanol solution. The loss of RR was significantly delayed in the group subjected to direct treatment (P < 0.001, chi-square test) and the connected group( P < 0.01 , χ2test ) compared to the control. The two former groups did not differ from each other significantly. UV spectra of Nux-v200 cH solution were similar to that of the water connected to the drug solution.
Conclusion:The anti-alcoholic effect of Nux-v 200 cH could be transferred through the body of a live toad to other groups of toads. The drug did not undergo denaturation during its passage through the living body. The fact that water carries the information of the original drug was further evidenced by the spectral properties of the water connected to the drug solution through capillary water
Source : Intl Journal High Dilutions
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A Research study showing the efficacy of Homoeopathic and Bio-chemic medicine for removing the habit of tobacco smoking and alcoholism.
Prof (Dr) M Abdul Lethif
Former Principal & Controlling officer of Homeopathy
Government Homoeopathic Medical College,Trivandrum
Abstract
Homoeopathic medicines were given to 652 patients after detailed study. Science, Technology and Environment Committee, Govt. of Kerala had given Rs.50,000/- as grant for a research study for two years from 15th December 1991. Follow up study was conducted on 279 patients while 373 was drop out. 71.43% was the success rate within two weeks and 23.8% after two weeks in alcoholics. In tobacco smoking the success rate was 62.18% within two weeks and 60.78% after two weeks. The success rate was 73.52% for alcoholics and 66.17% in tobacco addict in persons who used to drink and smoke cigarette. After two weeks the result was 33.23% and 38.97% in alcoholism and tobacco smoking respectively.
Source : homeobook.com
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A pilot Study of effectiveness of Homoeopathic Treatment in Management of Alcoholism
Dr.Binimol BHMS Under the Guidance of Dr.S.G.BIJU BHMS, MD (Hom)
Conducted At ATMTHA KENDRAM, Chabganacherry, Kottayam District, Kerala, S.INDIA
Introduction
Alcohol dependence syndrome - a neurological disorder is one of the major health/social/economic problem in Kerala. Alcoholism is a "dual disease" since it includes both mental and physical components. Long-term alcohol abuse produces changes in the brain's structure and chemistry such as tolerance and physical dependence. These changes maintain the person with alcoholism's compulsive inability to stop drinking and result in alcohol withdrawal syndrome if the person stops. Alcohol damages almost every organ in the body, including the brain. The cumulative toxic effects of chronic alcohol abuse can cause both medical and psychiatric problems. So it is a health issue rather than a social issue for any physician of any system of therapeutics. Homoeopathy put this disease under the most virulent and destructive miasmatic disorder, Syphilitic Miasm.
CONCLUSION
In this present study Alcoholism most commonly found in the age groups of 30 - 50 years and the incidence most common in Middle when comparing to the Upper and lower classes. Homoeopathic medicine found most effective in the treatment (67.5 %) is NUX VOMICA in 1M potency 2 doses daily morning and evening. Stramonium 200,Quracus Spiritus Q, Syphilinum 10M, Opium 1M,Medo 10M, Heparsuph 200, Merc Sol 1M, Sepia 1M, Staphisagria 10M, ArsAlb 0/3,Carcinocin 200,Agaricus M 200, Tuberculinum, are other remedies found effective in individual cases.
The selection of potency was done considering the stage of alcoholism, the intensity and frequency of the intake and the sensitivity of the individual patients. Thedose were repeated 2 doses per day as patient is having temptation to take alcohol 2wice a day in majority of cases. Many cases improved within 3 months and majority got relief by the sixth month. Permanent damage to the liver and other affected organs shall also be managed with medicines but proper investigation is necessary to avoid causalities.
This study reveals 3 major findings.
1. Alcoholism shall be treated without consent and knowledge of patient with Homoeopathic medicines..
2. Homoeopathic medicines shall offer 67.5% result in alcoholism within 180 days.
3. NUX VOMICA 1M twice a day is highly effective in management of alcoholism.
Source : similima.com
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