Research - Blatta orientalis
_Anti-asthmatic and anti-anaphylactic activities of Blatta orientalis mother tincture
Chetan Chandrakant Nimgulkar1,Savita Dattatray Patil2, B. Dinesh Kumar1
Abstract
Objectives
To study the anti-asthmatic and anti-anaphylactic activities of Blatta orientalis mother tincture (B. orientalis MT), a homeopathic medicine, in experimental animal models.
Methods
The anti-asthmatic activity of B. orientalis MT was studied in the bronchial hyperactivity models, acetylcholine and histamine induced bronchospasm, in guinea pigs. Anti-anaphylactic activity was tested by active and passive anaphylaxis models in rats, anti-eosinophilic activity was tested by milk-induced eosinophilia in mice.
Results
Significant protection against acetylcholine and histamine aerosol-induced bronchospasm in B. orientalis MT treated guinea pigs was seen. In active and passive anaphylaxis albino rat models significant reduction in mesenteric mast cells degranulation, serum IgE level and eosinophil cell count was observed in the B. orientalis MT treated rat group when compared with the sensitized control rat group.
Conclusion
These results reveal broad activity of B. orientalis MT. It may have nonselective anti-asthmatic activity. The anti-anaphylactic activity of B. orientalis MT may be due to mast cell stabilization, suppression of IgE and eosinophil cell count.
Source : Homeopathy Volume 100, Issue 3, July 2011, Pages 138–143
Link to Abstract
Chetan Chandrakant Nimgulkar1,Savita Dattatray Patil2, B. Dinesh Kumar1
- 1 Food and Drug Toxicology Research Centre, National Institute of Nutrition (ICMR), Hyderabad, Andhra Pradesh, India
- 2 Department of Pharmacology, R.C. Patel Institute of Pharmaceutical Education and Research, Karvand Naka, Shirpur, Dhule 425 405, Maharashtra, India
Abstract
Objectives
To study the anti-asthmatic and anti-anaphylactic activities of Blatta orientalis mother tincture (B. orientalis MT), a homeopathic medicine, in experimental animal models.
Methods
The anti-asthmatic activity of B. orientalis MT was studied in the bronchial hyperactivity models, acetylcholine and histamine induced bronchospasm, in guinea pigs. Anti-anaphylactic activity was tested by active and passive anaphylaxis models in rats, anti-eosinophilic activity was tested by milk-induced eosinophilia in mice.
Results
Significant protection against acetylcholine and histamine aerosol-induced bronchospasm in B. orientalis MT treated guinea pigs was seen. In active and passive anaphylaxis albino rat models significant reduction in mesenteric mast cells degranulation, serum IgE level and eosinophil cell count was observed in the B. orientalis MT treated rat group when compared with the sensitized control rat group.
Conclusion
These results reveal broad activity of B. orientalis MT. It may have nonselective anti-asthmatic activity. The anti-anaphylactic activity of B. orientalis MT may be due to mast cell stabilization, suppression of IgE and eosinophil cell count.
Source : Homeopathy Volume 100, Issue 3, July 2011, Pages 138–143
Link to Abstract