Research - Cardiac Insufficiency
_Efficacy of a homeopathic Crataegus preparation compared with usual therapy for mild (NYHA II) cardiac insufficiency: results of an observational cohort study
Abstract
Übjectives: To compare the efficacy of the homeopathic Crataegus preparation Craionin for non~inferiority to standard treatment for mild cardiac insufficiency.
Methods: Muiticentre nomrandotnised cohort Study in patients aged 50-75 years in New York Heart Association class H. Patients received Cralonin or ACE inhibitor/diuretics (n=102) for 8 Weeks. To adjust for confounding by baseline factors, populations were stratified according to propensity score. After adjusting, there were no statistically significant differences between treatment groups. Treatment efficacy was assessed on 15 variables. A stringent non-
inferiority criterion for the upper limit of the 97.5% confidence interval of the treatment difference was set to
the standard deviation (S.D.).
Results.' Both treatment regimens improved scores on most variables studied, with the greatest
effect on double product after exercise (average score reduction 15.4% with Cralonin vs. 16.0% for the control group). Stringent non-inferiority of Cralonin was demonstrated on 7 variables. Mediumstrìngent (O.5><S.D.) non-inferiority was indicated by 13 variables (exceptions: systolic blood pressure (BP) during exercise and diastolic BP at rest; for these, differences between treatments were not significant). Both treatments were well tolerated.
Conclusion: The Crczmegus-based preparation Cralonin is non~inferi0r to usual ACE inhibitor/ diuretics treatment for mild cardiac insufficiency on all parameters except BP reduction,
Source : Dr. Nancy Malik Google Documents via European Society of Cardiology
Link to Full Article
Abstract
Übjectives: To compare the efficacy of the homeopathic Crataegus preparation Craionin for non~inferiority to standard treatment for mild cardiac insufficiency.
Methods: Muiticentre nomrandotnised cohort Study in patients aged 50-75 years in New York Heart Association class H. Patients received Cralonin or ACE inhibitor/diuretics (n=102) for 8 Weeks. To adjust for confounding by baseline factors, populations were stratified according to propensity score. After adjusting, there were no statistically significant differences between treatment groups. Treatment efficacy was assessed on 15 variables. A stringent non-
inferiority criterion for the upper limit of the 97.5% confidence interval of the treatment difference was set to
the standard deviation (S.D.).
Results.' Both treatment regimens improved scores on most variables studied, with the greatest
effect on double product after exercise (average score reduction 15.4% with Cralonin vs. 16.0% for the control group). Stringent non-inferiority of Cralonin was demonstrated on 7 variables. Mediumstrìngent (O.5><S.D.) non-inferiority was indicated by 13 variables (exceptions: systolic blood pressure (BP) during exercise and diastolic BP at rest; for these, differences between treatments were not significant). Both treatments were well tolerated.
Conclusion: The Crczmegus-based preparation Cralonin is non~inferi0r to usual ACE inhibitor/ diuretics treatment for mild cardiac insufficiency on all parameters except BP reduction,
Source : Dr. Nancy Malik Google Documents via European Society of Cardiology
Link to Full Article