Research - Kidney Disease
Homoeopathic preparation of Berberis vulgaris as an inhibitor of Calcium oxalate crystallization: An in vitro evidence
Thellamudhu Ganesan1, Divya Bhavani Ravi1, Jyothilakshmi Vasavan1, Anil Khurana2, Debadatta Nayak2, Kalaiselvi Periandavan1
1 Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, Tamil Nadu, India
2 Deputy Director (H), Central Council for Research in Homeopathy, New Delhi, India
Abstract
Background: Berberis vulgaris is the most widely used drug in Homoeopathy for treating urolithiasis. However, its mechanism of action in alleviating its consequences remains uncertain.
Objective: To explicate the potential role of Homoeopathic preparation of B. vulgaris on in vitro Calcium oxalate (CaOx) crystallization.
Materials and Methods: Spectrophotometric crystallization assay was carried out, and the slopes of the nucleation (till the maximum) and aggregation (after the peak) phases were calculated using linear regression analysis, and the percentage inhibition exerted by the modifiers was calculated. Light microscopic observation of CaOx crystals formed in the presence or absence of modifiers was carried out to support the outcome with spectrophotometric crystallization assays and to ascertain the potential role of B. vulgaris in CaOx crystallization.
Results: The crystallization studies performed so far signifies B. vulgaris to be a potent drug against CaOx crystallization both at the level of nucleation and aggregation.
Conclusion: Our present findings add up to the experimental evidence to support the efficacy of the homeopathic preparation of the B.vulgaris in modulating the primary events of stone formation.
Source : Indian Journal of Research in Homeopath
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Preliminary investigation on ultra high diluted B. vulgaris in experimental urolithiasis
Vasavan Jyothilakshmi, Ganesan Thellamudhu, Alok Kumar, Anil Khurana, Debadatta Nayak, Periandavan Kalaiselv
Abstract
Purpose
The study focuses on the anti-urolithiasis potential of ultra-diluted homeopathic potency of Berberis vulgaris (B. vulgaris) root bark, commonly used in homeopathic system to treat renal calculi.
Methodology
B. vulgaris root bark (200c, 20 μl/100 g body weight/day, p.o, for 28 days) was tested in an animal model of urolithiasis. Urolithiasis was induced in male Wistar rats by adding 0.75% ethylene glycol (EG) to drinking water. Urine and serum samples were analyzed for calcium, magnesium, phosphorus, uric acid and creatinine. Enzymic makers of renal damage (alkaline phosphatase, lactate dehydrogenase, leucine aminopeptidase and γ-glutamyl transpeptidase) were assessed in kidney and urine. Renal tissues were analyzed for oxalate content.
Results
Administration of EG to rats increased the levels of the stone-forming constituents calcium, phosphorus and uric acid, in urine. Levels were normalized by B. vulgaris treatment. The decrease in the urolithiasis inhibitor magnesium in urine was prevented by treatment with B. vulgaris. Serum creatinine levels were largely normalized by B. vulgaris treatment. Hyperoxaluria induced renal damage was evident from the decreased activities of tissue marker enzymes and an apparent escalation in their activity in the urine in control animals; this was prevented by B. vulgaris treatment.
Conclusion
Homeopathic B. vulgaris root bark has strong anti-urolithiasis potential at ultra-diluted dose.
Source : Homeopathy
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A case of idiopathic nephrotic syndrome treated with the homeopathic therapeutic
Luiz Figueira Pinto
Federal Rural University of Rio de Janeiro, RJ, Brazil
ABSTRACT
Nephrotic syndrome is a chronic clinical condition and drugs used in its treatment may result in severe side effects. Renal transplantation or renal ablation and subsequent chronic dialysis treatment may be the only feasible way to patients. The present article reports the case of a 23- years-old white woman that presented nephrotic syndrome and was successfully treated with homeopathic medicines. Six kind of homeopathic diagnoses were made to build the clinical homeopathic picture of the patient and to determine the appropriate medicines, according to the clinical protocol used. Apis mellifica was the main medicine used to treat the diathesis sycosis. The satisfactory treatment outcome shows that the judicious homeopathic therapeutic may be a valuable resource in the treatment of nephrotic syndrome.
Source : Int J High Dilution Res 2009; 8(26):26-32
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